High-performance computing (HPC) systems provide fundamental computing infrastructure and play a pivotal role in economic competitiveness and scientific discovery. Security is an essential component of HPC. NIST HPC Security Working Group (WG) has been leading the effort to create comprehensive and reliable security guidance for HPC systems. As part of the Working Group mission and to reach the greater HPC scientific community, NIST, in collaboration with the National Science Foundation (NSF), will host the 5th High-Performance Computing Security Workshop on May 7-8, 2025. The workshop aims to listen to the community’s needs and feedback, report and reflect on the ongoing activities at HPC Security WG, and define and discuss future directions with stakeholders from industry, academia, and government.